Longevity⁺ Corner: What Is An NRF2 & What Foods Does It Like?

Great video — NRF2 is a “Leucine Zipper” protein

NRF2 stands for Nuclear factor-erythroid factor 2-related factor 2 —say that 10 times fast — and is a “DNA transcription factor” protein that regulates and enhances how genes are expressed by binding to it.

It’s a complex other world inside the human body, yet perhaps we can understand better by comparing with the outer world and across subjects.

Many sources refer to NRF2 as “master regulator” or “mediator” of immune response, including inflammation and autophagy, and induces production of protective antioxidants.

The descriptions sound like a maintenance tech, promoter or consultant. And somewhat musically, it contains a structural ‘motif’ called “Leucine zipper.”

Leucine is an essential amino acid used for building proteins. Proteins are compounds fundamentally composed of carbon, nitrogen, hydrogen, oxygen. The strands of amino acids arrange like a great tapestry.

Here’s a great biology channel I came across, which provides a clear explanation of Leucine Zipper:

Shomu’s Biology

Back to NFR2: Identified by its sequence, NRF2 resides in the Cytosol of a cell and when activated or signaled as a result of oxidative stress, follows a pathway to assist the DNA. Overall signal strength is associated with robust health, while the opposite is associated with “age-related disorders” as mentioned in the article below.

Image from a great article highlighting strength of NRF2 and preventing “age-related disorders: https://www.mdpi.com/1422-0067/20/13/3208/htm

Balance is key, because overactivation can cause issues as well. For this reason, a delicious nutrient dense menu seems the way to go here.

Here’s a list of “pro-Nrf compound” foods from http://centerforwellnessmedicine.com/nurf-what/ :

  • Garlic and onion (sulfur compounds)
  • Broccoli, broccoli sprouts, cabbage, kale, collard greens, cauliflower, bok choy, and Brussels sprouts (sulforaphane), purple sweet potato (carotenoids, anthycyanins)
  • Grapes, cranberries, blueberries, mulberries, lingonberries, bilberries, jackfruit, peanuts and chocolate! (resveratrol)
  • Olives and olive oil (oleuropein)
  • Pomegranate (delphinidin, cyanidin, and pelargonidin)
  • Green tea (Epigallocatechin-3-gallate, or EGCG).
https://www.geogebra.org/m/ab2bahmj

Lastly, I have to bring up electromagnetism again as I research and attempt to understand these details. The interaction of DNA transcription protein with the DNA reminds me of the interaction of the electric and magnetic fields, which are indeed shaping forces that create matter — Two forces come together at an axis, or point, and that creates dimension. (I think that’s part of what the black cube at Mecca celebrates.) The graphic above clearly resembles a helix and if you visit the link you can see it in motion.

Even the proteins themselves look wave-shaped, of different amplitudes, if you will, depending on complexity of structure. This why I’ve been supposing that sound and light will be especially effective in the burgeoning fields of regenerative and noninvasive medicines.

“Some words cannot be said. Some stories won’t be read or reach the end. Some lines cannot be crossed.” — Serendipitously, the music I’m listening to as I type = “Twisted Act” by Chris Element 😉 part of Paul Van Dyk’s VONYC Sessions broadcast

I don’t know, we’ll see. I think computing and AI will continue to be extremely useful in sorting out all these complexities. It certainly is a different world in there — the micro world, and certainly the quantum energetic world — yet, similar as layers of the same larger shared existence.

1. Vomund S, Schäfer A, Parnham MJ, Brüne B, von Knethen A. Nrf2, the Master Regulator of Anti-Oxidative Responses. Int J Mol Sci. 2017 Dec 20;18(12):2772. doi: 10.3390/ijms18122772. PMID: 29261130; PMCID: PMC5751370. https://pubmed.ncbi.nlm.nih.gov/29261130/

Published by sarah ikerd

@sarah.ikerd / owner

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